Along with CXCL6 and CXCL8, VEGF, ICAM1, VCAM1, and SELE can also be directly induced by SAA in heatmap analysis, which was consistent with previously substantial evidence in dermal human microvascular endothelial cells (HMVECs) (40), rheumatoid arthritis (RA) synovial fibroblasts (41), and giant cell arteritis (GCA) myofibroblasts (42). Here, VEGFA is linked to rheumatoid arthritis.