Currently, the traditional anti-depressants like selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in combination with other drugs like cholinesterase inhibitors, monoamine oxidase inhibitors depending upon the type of neurodegenerative disease present along with depression, are being used for the treatment of depression in patients with neurodegenerative diseases [8,10,25]. Here, BCHE is linked to major depressive disorder.