Through in silico analysis, we found a large number of target genes of miR-125a-3p, among which NNMT, a cytosolic enzyme, most sparked our interest because it has been identified as an oncogene in a series of human cancers, including LUAD (Sartini et al., 2013; Eckert et al., 2019), which is also verified by the results from the UALCAN7 online analysis tool (data not shown). Here, NNMT is linked to cancer.