The mRNA and protein expression profiles of these seven genes using the expression data from TCGA-PC and GEO (GSE28735 and GSE62452) cohorts and the HPA database revealed that PLAU, CXCL10, CXCL9, MET, and IL1RN were overexpressed, whereas PAH and PKD1 were downregulated in PC tissues. The gene discussed is IL1RN; the disease is pachyonychia congenita.