As shown in Figures 9A,B, among the seven hub genes, the expression levels of PLAU, CXCL10, CXCL9, MET, and IL1RN were significantly elevated, whereas the expression levels of PAH and PKD1 were significantly decreased in PC samples compared with those in the normal pancreas samples. The gene discussed is CXCL9; the disease is pachyonychia congenita.