A similar prognostic trend was also discovered in the validation cohort (Supplementary Figure 1), whereas only genes PLAU and MET genes were significantly associated with the prognosis of patients with PC (P < 0.05), which might be due to the small number of PC samples and the unequal composition of patients with PC (in the validation cohort, no PC patient had an overall survival of more than 3 years). The gene discussed is PLAU; the disease is pachyonychia congenita.