DHCR7 and Smith-Lemli-Opitz syndrome: Cholesterol is of critical importance to brain development; mutations in DHCR7 gene leads to Smith-Lemli-Opitz Syndrome, a neurodevelopmental condition, and exposure to DHCR7 inhibitors during the first trimester of pregnancy is associated with increased rates of fetal malformations, intrauterine death, and spontaneous abortions (Boland and Tatonetti, 2016).