It is possible that TMEM119 and P2RY12 are not microglia-specific in the inflamed CNS, or that the inflammatory milieu in stroke, coupled with the prolonged time MDMs spend in the CNS, enables them to acquire a microglia-like phenotype, particularly as the CNS microenvironment ordinarily defines microglial phenotype and identity (150, 191). This evidence concerns the gene P2RY12 and stroke disorder.