Then, at the systemic level, the possibility of relating coronary and cerebrovascular diseases associated with this autoimmune mechanism has also been described, since elevated serum levels of antibodies against human HSP60, during the course of periodontal disease, may have a cross-reaction with gingival tissue, vascular endothelium and smooth muscle or the possibility of deteriorating pre-existing lesions (92) (Figure 1C). Here, HSPD1 is linked to periodontal disorder.