It has been described that the participation of B-cells in the microbiome host interaction at the intestinal level, goes beyond the promotion of Breg cell differentiation and its production of IL-10 through the activation of IL-1β and IL-6; commensals seem to play a key role in the removal of autoreactive B-cells from the gut associated lymphoid tissue, a process that is defective in SLE and RA, so a lack of regulatory promoting bacteria that compromises synthesis or secretion of immunoglobulins could be hypothesized (40). The gene discussed is IL10; the disease is systemic lupus erythematosus.