Epigenetic regulations could break the immunological homeostasis and result in the development of autoimmune diseases (40) such as SLE, RA (214), Systemic sclerosis (215), Sjogren syndrome (216), etc, among others due to the inflammatory responses mediated by an increase in the number of iNKT, less reactivity of the NK, and alteration of production IFN type I, IL-6, IL-12, IL-18 and TNF-α (22). The gene discussed is IL6; the disease is rheumatoid arthritis.