PRF1 and systemic lupus erythematosus: Other epigenetic modification described for the SLE are DNA methylation and histone modifications which regulate gene expression in mature T cells for different genes such as CD11a, perforin, CD70, and CD40LG are described in the literature (218), as well as overexpression of IL10 in T cells from SLE patients leading to an increase of specific autoantibody production and tissue damage (219).