TFEB and periodontitis: It has recently been described in a mouse model of periodontitis with RA, that the modulation of cathepsin K-mediated TLR9-related autophagy, can decrease bone destruction in periodontitis promoted by RA, by modulating the infiltration of macrophages, TLR9, autophagy proteins (TFEB and LC3) and inflammatory cytokines (149) (Figure 1G).