IRF7 and viral infectious disease: In total 20 ISGs were significantly upregulated in the RSV-infected mice compared to the non-infected mice (Supplementary Table 1) and some of the top 10 upregulated genes, such as Irf7,Cxcl10, Ccl2, and Ccl4, are all ISGs known to be induced in response to viral infections (21–24).