BRD2 and lymphoma: A metanalysis of three randomized clinical trials and four case-control series, including a total of 434 lymphoma patients under systematic chemotherapy, deduced that GnRHa treatment seemed to decrease the incidence of COF, defined as increased FSH level, by 68% (OR 0.32 95% CI, 0.13–0.77, p = 0.01) (22).