Moreover, in a small study pre- and post-menarchal patients treated for Hodgkin and non-Hodgkin lymphoma, thymoma, acute myeloid, and lymphoid leukemia, GnRH treatment confined a more notable benefit in preserving menstruation and fertility in postpubertal patients, whereas prepubertal girls seemed to be at less risk of COF, even in the absence of GnRH treatment (25). This evidence concerns the gene GNRH1 and non-Hodgkin lymphoma.