Experimental studies on murine corticotroph pituitary tumor cell lines and human corticotroph pituitary tumor cell cultures demonstrated that pasireotide induced a significant decrease in ACTH secretion (4, 7); interestingly, the inhibition of ACTH secretion was maintained even in cultures pre-incubated with dexamethasone, supporting the hypothesis of a predominant role of SSTR5 in the regulation of corticotroph cell secretion during chronic hypercortisolism (7, 10). The gene discussed is SSTR5; the disease is pituitary tumor.