In the in vivo evaluation in athymic nude mice injected with AtT20 corticotroph tumor cell line, with consequent development of local subcutaneous corticotroph tumors, representing a model of CD, roscovitine induced a reduction of tumor mass of about 50% compared with controls after 3 weeks of treatment, together with a decrease in plasma ACTH and serum corticosterone levels, which were significantly lower in mice treated with roscovitine than in controls (46). Here, POMC is linked to neoplasm.