CXCR3 and myeloid sarcoma: In addition to the secretion of proinflammatory cytokines known to be elevated in MS patients, the encephalitogenicity of TH17.1 cells is also attributed to the enhanced brain-homing potential imparted by the simultaneous expression of CXCR3, CCR6, and VLA-4, all of which are important for trafficking to the inflamed CNS.