Geng et al. found that miR-143 is significantly reduced in exosomes derived from the serum of patients with myocardial infarction, which promotes angiogenesis of myocardial ECs by targeting insulin-like growth factor 1 receptor (IGF-IR) and the production of NO (Geng et al., 2020). Here, IGF1R is linked to myocardial infarction.