Moreover, as TLRs ligands, LPS was reported to increase breast cancer metastasis in vitro and in vivo (Li et al., 2017), and acquiring of high metastatic potential upon the TLR4-elicited activation of NF-κB in breast cancer cells was associated with integrin αvβ3, TPM1 and maspin (Liao et al., 2012). This evidence concerns the gene SERPINB5 and breast cancer.