However, some literature (Savage et al., 2014; Zhou et al., 2019) pointed out that Bclaf1 promotes the transcription of HIF-1α in hypoxic liver cancer cells through the bZIP domain, thereby increasing the transcription of downstream targeting factors of HIF-1α and promoting the proliferation of HCC cells. The gene discussed is BCLAF1; the disease is hepatocellular carcinoma.