HIF1A and liver cancer: Expression levels of HIF-1α in human liver cancer cells decreased after Bclaf1 knockout in a 1% O2 environment and significantly increased after Bclaf1 overexpression; furthermore, Anwen Shao et al. (Shao et al., 2020) reported Bclaf1 was a direct transcriptional target of HIF-1 and upregulated in multiple cell lines during hypoxia.