Wnt signaling plays a pivotal role in CXCL12-induced tumor cell proliferation, as silencing CXCL12/CXCR4 signaling influences pancreatic cancer cell phenotypes and inhibits tumor cell proliferation in vitro via inactivation of the canonical Wnt pathway (Wang et al., 2008b). Here, CXCL12 is linked to familial pancreatic carcinoma.