FYN and temporal lobe epilepsy: On the other hand, Fyn depletion attenuated seizure development in a mouse model of temporal lobe epilepsy (Chun et al., 2004; Sharma et al., 2018) while its overexpression enhanced seizure susceptibility (Cain et al., 1995; Kojima et al., 1998) as well as tau aggregation (Xia and Götz, 2014; Li and Götz, 2017).