MAPT and Cognitive impairment: In neurological diseases that manifest seizures, tau loss attenuates resistance to seizure induction (Ittner et al., 2010; DeVos et al., 2013) while Fyn reduction not only reduces seizures and seizure-induced mortality (Sharma et al., 2018), but also suppresses tau pathology, neuroinflammation, and cognitive deficits (Kaufman et al., 2015; Tang et al., 2020).