PrognoScan database was explored to investigate the effect of KLHL5 expression on patients' prognosis across 13 tumor types (Supplementary Tables 2–5), and we observed a significant correlation between patient prognostic outcomes and KLHL5 expression in 7 of the 13 types including soft tissue, mammary, brain, colorectal, lung, ovarian, and blood cancer (Figures 2A–H). Here, KLHL5 is linked to neoplasm.