KLHL5 and gastric cancer: As lymphatic route is the most common way for gastric cancer cell metastasis and lymph node status is directly correlated with patient prognosis (Deng and Liang, 2014), the finding that correlation between KLHL5 and stage N2 has the highest ratio of OS and PFS except for stage 2 and tumor size stage 4 indicates that KLHL5 overexpression has an impact on patient prognosis, possibly by shaping lymph node metastases in gastric cancer.