Moreover, the up-regulation of FAM83D mRNA and protein levels were detected in human gastric cancer tumor tissues and cell lines, comparing with the adjacent normal tissues and non-malignant gastric epithelial cell lines, respectively, and that reversed relationship shown between OS, DFS, and FAM83D in gastric cancer patients (Wang F. et al., 2019). The gene discussed is SACK1D; the disease is gastric cancer.