In the early 2000's, Lazarevich et al. (33) not only found a strong correlation between the downregulation or lack of function of HNF4A and the progression of hepatocellular carcinoma (HCC), but also that restoration of HNF4A expression could reverse the HCC phenotype in a mouse model. The gene discussed is HNF4A; the disease is hepatocellular carcinoma.