PMPs in lung cancer cells can induce the mRNA expression of MMP-9, VEGF, IL-8, and HGF in HUVECs (Janowska-Wieczorek et al., 2005), mediate angiogenic functions by VEGF, PDGF, TGF-β, and bFGF (Haemmerle et al., 2018), and stimulate the proliferation, chemotaxis and tube formation of HUVECs (Kim et al., 2004). The gene discussed is VEGFA; the disease is lung cancer.