CXCL8 and glioblastoma: Due to hypoxia-induced transcriptional reprogramming, hypoxic glioblastoma cells secreted pro-angiogenic cytokines-enriched EVs (enriched in MMPs, IL-8, etc.)that are more effective in stimulating tumor growth and vessel formation than the EVs secreted by normoxic glioblastoma cells (Kucharzewska et al., 2013).