The G protein-coupled sphingosine-1-phosphate (S1P) receptor one S1P1 was significantly lower in ECs from Wnt-medulloblastoma, secondary colorectal cancer, and HCC than in normal ECs, and negatively correlated to miR-9-2 in Shh-medulloblastoma ECs (Yao et al., 2020). This evidence concerns the gene S1PR1 and hepatocellular carcinoma.