A recent study found that tumor growth in some patients with glioma is independent of the VEGF pathway (García-Romero et al., 2020), while other instances (e.g., high dose of bevacizumab in glioma) indicated that AATs suppress tumor independently from vascular regression (von Baumgarten et al., 2011), showing complex roles of VEGF in tumor progression. This evidence concerns the gene VEGFA and central nervous system cancer.