CD274 and neoplasm: A large number of studies indicated that the expression of PD-L1 (Patel and Kurzrock, 2015; Chang et al., 2018), tumor mutation load (TMB) (Chan et al., 2019; Liu et al., 2019), microsatellite instability (MSI) (Chang et al., 2018; Luchini et al., 2019; Zhao et al., 2019), and mutations in specific genes (Dong et al., 2017a; Xiao et al., 2018) can predict the efficacy of ICIs.