Under the background of HNSC, related studies noted that some characteristics, such as PD-L1 (Ferris et al., 2016), MSI (Tardy et al., 2018), HPV infection (Zandberg et al., 2019), TMB (Hanna et al., 2018), and tumor lymphocyte infiltration (Hanna et al., 2018), may be predictors of immunotherapy efficacy. The gene discussed is CD274; the disease is neoplasm.