SERPINE2 and cancer: Previous studies have shown that the abnormal expression of SERPINE2 is involved in the occurrence and development of various cancers: mammary, pancreatic, prostatic, esophagus, gastric, colorectal cancer, etc. Fayard et al. (2009) reported that SERPINE2 can bind to LRP1, stimulate extracellular kinase signal, and regulate the invasion and metastasis of mammary tumor.