TNF and COVID-19: On the other hand, SARS-CoV-2 can activate excessive and damaging immune inflammatory response in COVID-19, which is called “cytokine storm.” Mononuclear phagocytes are over proliferated with accumulated interleukin (IL)-6, IL-7, tumor necrosis factor (TNF), inflammatory chemokines CCL2, CCL3, and CXCL10 (Pedersen and Ho, 2020).