GLS and pancreatic adenocarcinoma: For example, miR-605-5p was markedly downregulated in melanoma tissues and cells and inhibited melanoma progression and glutamine catabolism through targeting GLS (Lu et al., 2020); miR-876-3p functioned as a tumor suppressor and correlated with cell metastasis in pancreatic adenocarcinoma via targeting JAG2 (Yang et al., 2018).