ATG5 and atherosclerosis: Likewise, atherosclerosis-prone mice bearing an endothelial-specific deletion of Atg5 develop larger atherosclerotic lesions, specifically in areas exposed to high shear stress (Vion et al., 2017), that commonly remain lesion-free since atherosclerosis favorably develops at arterial bifurcations and at the inner part of curvatures where blood flow is low or disturbed (Hsieh et al., 2014).