Dysregulation of PADI4 is involved in the occurrence and development specific human diseases, such as tumor development (Chang and Fang, 2010), multiple sclerosis (Mastronardi et al., 2006), and rheumatoid arthritis (RA) (Suzuki et al., 2003; Guzmán-Guzmán et al., 2015). Here, PADI4 is linked to neoplasm.