In an LPS-induced abortion mouse model, TSG-6-silenced or CD200-silenced MSCs exhibited a higher embryo resorption rate and both had higher levels of TNFα, IFNγ, and induced nitric oxide synthase (iNOS) in the decidua than non-silenced control MSCs supporting the CD200- (cell-mediated) and TSG-6-dependent (i.e., paracrine-mediated) mechanism (Li et al., 2019) (Figure 3C). This evidence concerns the gene TNFAIP6 and abortion.