CD274 and metastatic melanoma: Moreover, previous research has shown that, in patients with metastatic melanoma (Taube et al., 2012), colorectal cancer (Droeser et al., 2013), Merkel-cell carcinoma (Lipson et al., 2013), and EC (Liu et al., 2015), higher PD-L1 expression was correlated with improved overall survival rates, suggesting that high PD-L1 expression may be a favorable prognostic marker in several types of cancer.