PCA3 and posterior cortical atrophy: The fact that prostate epithelial cells are released in the urine from the prostate gland in PCa patients and urine biomarkers can be used as PCa diagnostic tests (such as PCA3) (Groskopf et al., 2006) supports the usage of the 14-Gene Panel in a urine test to distinguish between higher-risk PCa and lower-risk PCa.