Ensues with aging (Mirza et al., 2010; Ota et al., 2013). Lower sclerostin level in osteoporosis patients (Reppe et al., 2015). Ablation of Sost showed an increasing trend of lean body mass in elderly animals (Kim S.P. et al., 2017). A positive relevance between sclerostin and sarcopenia in type 2 diabetes mellitus (Medeiros et al., 2020). The gene discussed is SOST; the disease is osteoporosis.