Tissue injury or infection triggers the release of a train of signals, including damage-associated molecular patterns (DAMPs), pathogen-associated molecular patterns (PAMPs), lipid mediators and chemokines, such as formylmethionyl-leucyl-phenylalanine (fMLP), ATP, high mobility group box-1 (HMGB1), F-actin, N-glycan, LTB4, CCR1 ligands, chemokine (C-X-C motif) ligand (CXCL) 2, and CXCL8, from injury sites (McDonald and Kubes, 2010; Selders et al., 2017; Peiseler and Kubes, 2019; Gong et al., 2020). The gene discussed is HMGB1; the disease is infection.