Additional chromosomal rearrangements were also reported in adult T-cell leukemia/lymphoma (ATLL) t(2;14)(q34;q32) and acute myeloid leukemia (AML) t(2;14)(q22.3;q32.2) leading respectively to the formation of a HELIOS-BCL11B (Fujimoto et al., 2012) and a ZEB2-BCL11B fusion protein (Torkildsen et al., 2015; Padella et al., 2019). Here, BCL11B is linked to acute myeloid leukemia.