It was observed by Bao et al. that as a histone methyltransferase, EZH2 could be recruited in the miR-454-3p promoter to induce miR-454-3p DNA methylation and thus decrease miR-454-3p expression in chondrosarcoma cells (Bao et al., 2017), which was coincident with our results that EZH2 inhibited miR-454-3p by DNA methylation. This evidence concerns the gene PRDM9 and chondrosarcoma.