Immunofluorescence results depicted that silencing EZH2 by lentivirus obviously reduced the expression of M2 macrophage polarization-related indicators (CD206, MIP-3α, and IL-8) but potently increased the expression of IL-6 in the glioma tissues of nude mice (Figures 2I,J). The gene discussed is CXCL8; the disease is glioma.