CD4 and malaria: Accumulated findings indicated that TIM-3 was responsible for inhibiting T lymphocytes (CD4+ Th1/Th2, CD8+, and γδ T cells), NK cells, and macrophages responses to malaria treatment (Hou et al., 2016; Hou et al., 2017; Sabins et al., 2017; Schofield et al., 2017; Otterdal et al., 2018).