LAG3 and neoplasm: Lymphocyte Activation Gene-3 (LAG-3) is expressed by many cells, including NK cells, T cells, B cells, and tumor infiltrating lymphocytes (Huang et al., 2004). As the T cell receptors, LAG-3 directly and indirectly induces transcriptional changes, which negatively modulates proliferation and pro-inflammatory cytokines expression by virus-specific CD8+ T cells (Barber et al., 2006; Blackburn et al., 2009).