CD8A and neoplasm: It is unexpected and needs further validation that Faecalibacterium/Prausnitzii was identified as enriched in non-responders compared to responders (Figure 3) and also enriched in non-responders before nCRT compared to after nCRT (Supplementary Figure 5), since Faecalibacterium/Prausnitzii was suggested to be positively correlated with CD8+ T cell infiltrate in the tumor and favorable responses to anti–PD-1 immunotherapy (Gopalakrishnan and Spencer, 2018).