The high expression of KCNQ1 observed in well-differentiated CRC cells and its locking of β-catenin with E-cadherin (encoded by CDH1 gene) into adherens junctions serves two purposes to inhibit or delay EMT and cell proliferation by promoting an epithelial phenotype and preventing nuclear transcription of β-catenin targeted proliferative genes, loss of cell polarity and progression to EMT. Here, CDH1 is linked to colorectal carcinoma.