Sustained expression of KCNQ1 protein was linked to suppression of the Wnt/β-catenin signaling pathway and the expression of KCNQ1 was lost with increasing mesenchymal phenotype in poorly differentiated CRC cell lines as a consequence of repression of the KCNQ1 promoter by β-catenin:TCF4. This evidence concerns the gene TCF4 and colorectal carcinoma.