SHM is not completely restricted to the IgV genes and can also target some non-Ig genes, including the proto-oncogene BCL6. This off-target SHM is particularly extensive in some types of lymphomas, including diffuse large B cell lymphoma (DLBCL), and is therefore termed aberrant SHM (60–62). This evidence concerns the gene BCL6 and diffuse large B-cell lymphoma.