If the concept of two types of BCR signaling is applied to lymphoma, a tonic BCR stimulation pattern plays a major role in GCB-DLBCL, mainly mediated by a Y188 mutation within CD79A, and in a relevant subgroup of BL accompanied by mutations in TCF3 and ID3, and activation of the PI3K pathway (83, 84). This evidence concerns the gene BCR and diffuse large B-cell lymphoma.