For lymphoplasmocytic lymphoma, for ABC-DLBCL, and for PCNSL, the search for specific substances to modulate the immunogenic PTMs of hyper-phosphorylated SLP2 and sumoylated HSP90 in LPL, of N-hyperglycosylated SAMD14/neurabin-I in PCNSL and of hypophosphorylated ARS2 in DLBCL would be useful. The gene discussed is LPL; the disease is primary central nervous system lymphoma.