Some ALK fusions that were less commonly reported in NSCLC (i.e., non-canonical ALK fusions) include kinesin family member 5B (KIF5B)-ALK, TRK-fused gene (TFG)-ALK, kinesin light chain 1 (KLC1)-ALK, striatin (STRN)-ALK, and TNFAIP3 interacting protein 2 (TNIP2)-ALK (7–10), while some ALK fusions were mainly found in other cancers, for example, nucleophosmin (NPM)-ALK fusion was almost exclusively found in large cell lymphomas (11). The gene discussed is KLC1; the disease is cancer.