CXCL1 and metastatic malignant neoplasm in the lymph nodes: Moreover, CXCL1 mRNA expression was upregulated in the LVSI+LN+ group compared to that in the LVSI+LN- group, suggesting that the high expression of chemokine CXCL1 may be involved in the recruitment of neutrophils to lymph vessels during the progression of lymph node metastasis in EEA.