TGFB1 and neoplasm: The clinical and experimental research has provided evidence that the number of myofibroblasts in tumor stroma is a tumor promoter (Kellermann et al., 2007; Surowiak et al., 2007), while growth factors such as TGF-β secreted from myofibroblasts promote cell proliferation and proteolytic enzymes that degrade the matrix (Baglole et al., 2006; Bhowmick, Neilson & Moses, 2004; Desmoulière, Guyot & Gabbiani, 2004).