Previous studies have shown that dysregulation of circulating miR-210 in BC is associated with tumor presence and lymph node metastasis in patients with HER-2 positive BC (Jung et al., 2012), metastases (Markou et al., 2016; Madhavan et al., 2016) and resistance to chemotherapy (Jung et al., 2012; Shao et al., 2019). This evidence concerns the gene ERBB2 and breast cancer.