EZH2 and neoplasm: Similarly, in C2C12 myoblasts, the increased expression of miR-26a occurs alongside the induction of cell differentiation, expression of muscle-specific genes myoD1 and myogenin, and Ezh2 downregulation of Chung and Tellam (2008), whereas in rhabdomyosarcoma tumor cells miR-26a expression is lower and EZH2 is higher (Ciarapica et al., 2009).