Surprisingly, some researches have verified that the repression of HNRNPC can inhibit two breast cancer cell lines (MCF7 and T47D) proliferation through the accumulation of double-stranded RNA (dsRNA), the binding ligand of RIG-I, and anti-proliferation activity induced by the stimulated IFN cytokine (Wu et al., 2018). Here, RIGI is linked to breast carcinoma.