Furthermore, the nine-gene signature prognostic model (ARHGEF38-IT1, CCDC15, CPZ, DNASE1L2, NUDT10, PASK, PLCL1, PRR5-ARHGAP8, and SYCE2) constructed in this study was significantly related to the overall survival, clinical characteristics, tumor microenvironment immune cells, TMB, and cancer-related pathways. This evidence concerns the gene SYCE2 and cancer.