In our work, correlation analysis indicated that ACOT8 expression was positively related to ferroptosis-suppressing GPX4, but was negatively correlated with ferroptosis-promoting HIF-2α, HILPDA, and TAZ in a total of three ccRCC datasets from TCGA and the GEO databases. The gene discussed is HILPDA; the disease is nonpapillary renal cell carcinoma.