GPX4 exerts protective roles in cells by using glutathione (GSH) to catalyze the reduction of lipid peroxides, and GPX4 inhibition was observed to be sufficient to kill ccRCC cell lines through ferroptotic cell death (Yang et al., 2014; Stockwell et al., 2020). The gene discussed is GPX4; the disease is nonpapillary renal cell carcinoma.