To investigate the potential association of ACOT8 with ferroptosis in ccRCC, we utilized three online ccRCC datasets to perform correlation analysis on ferroptosis-related genes which had been publicly reported in ccRCC, including GPX4, HIF-2α, HILPDA, and TAZ (Yang et al., 2014, 2019; Zou et al., 2019). The gene discussed is ACOT8; the disease is nonpapillary renal cell carcinoma.