High expression of ACOT1 is related to unfavorable prognosis of gastric adenocarcinoma via increased tumor-promoting protein GLI3 (Wang et al., 2018), while ACOT8 is demonstrated to be an independent predictor of lymph node metastasis and survival of lung adenocarcinoma (Jung et al., 2013). This evidence concerns the gene ACOT1 and metastatic malignant neoplasm in the lymph nodes.