In light of recent findings on RAN translation and the presence of RNA nuclear foci in Huntington’s disease (Zu et al., 2011; Banez-Coronel et al., 2015; Rue et al., 2016; Cleary and Ranum, 2017; Urbanek et al., 2017), the distinction between the two types of toxicity has blurred. The gene discussed is RAN; the disease is Huntington disease.