CLCA1 and asthma: We found key asthma-associated genes including the T2-high signature genes of CLCA1, POSTN, and SERPINB2 (Woodruff et al., 2007) as well as those not previously asthma-associated (e.g., CST1 and Vanin genes—VNN1–3) to be potentially influenced by aberrant H3K27ac (Figure 4B).