Although occurring primarily at intergenic sites genome-wide, asthma DERs were proximal to n = 3,062 genes and pathway analysis revealed that DER-associated genes contributed to epithelial (e.g., cellular adherens) and asthma-associated processes (e.g., TGF-β signaling) with up to 30% of all genes within these pathways exhibiting differential H3K27ac in asthma (range 19.9–30.1%, Figures 1C–E). The gene discussed is TGFB1; the disease is asthma.