Chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq) profiling of histone H3 Lys4 dimethylation (H3K4me2) in CD4+ T cells from individuals with asthma has identified putative asthma-associated enhancers (Seumois et al., 2014), supporting the use of genome-wide approaches to identify novel epigenomic mechanisms in asthma. This evidence concerns the gene CD4 and asthma.