NR3C1 and asthma: We observed 2.3% of asthma DERs (n = 101, P = 0.076 Fisher’s exact test) overlapped with GR-binding sites identified in dexamethasone (DEX)-treated airway epithelial cells (Kadiyala et al., 2016), suggesting that glucocorticoid treatment was not a primary cause of epigenome reorganization in these subjects (Supplementary Figure S1B).