CD4 and achalasia-alacrima syndrome: Furthermore, we found that the proportions of cells related to M1 macrophages, M2 macrophages, mast cell quiescence, monocytes, NK cell activation, and activated memory CD4+ T cells increased in AAAs, whereas those related to mast cell activation, NK cell quiescence (Figure 4C), quiescent memory CD4+ T cells (Figure 4E), and naïve CD4+ T cells (Figure 4F) increased in normal aortic samples.