Similarly, osteopontin (which is encoded by SPP1) is correlated significantly with tumor metastasis and a poor prognosis in cancers (Briones-Orta et al., 2017; Cabiati et al., 2017; Xu et al., 2017; Li et al., 2018; Zhao et al., 2019). This evidence concerns the gene SPP1 and neoplasm.