BGN and malignant colon neoplasm: Extensive studies have elucidated the crucial role of BGN in regulating the progression and metastasis of various malignancies, including prostate (Jacobsen et al., 2017), gastric (Hu et al., 2016), endometrial (Sun et al., 2016), and colon cancers (Jacobsen et al., 2017; Liu B. et al., 2018).